BioGenex provides a “Total Solution” for slide-based cell and tissue analysis to accelerate clinical diagnostics and drug discovery development. We have developed the total walk-away, industrial-scale automated systems to streamline and standardize an array of processes for cell and tissue testing in immunohistochemistry (IHC), in situ hybridization (ISH), Fluorescent in situ hybridization (FISH), special stains.
Our products include more than 400 antibodies (monoclonal and polyclonal) for various cancer panels, highly sensitive detection kits, automated systems, mRNA, miRNA, and FISH probes, ancillary reagents, and consumables. We accommodate diverse laboratory needs with an array of clinical and research automation platforms that meet global quality standards (ISO 13485 & ISO 9001), are approved by the FDA and CE-marked. BioGenex is a global market leader in molecular pathology providing customer-centric solutions for complete automation of cell and tissue staining. Through its cutting-edge and patented technologies, the company has transformed the practice of slide-based staining in many molecular pathology laboratories.
Overview of Immunohistochemistry (IHC)
Diagnostic pathology has exponentially advanced over the last few decades due to the implementation of various novel techniques. The most notable of these techniques for diagnosis is immunohistochemistry (IHC). BioGenex, a pioneer in molecular pathology solutions and precision medicine, has been serving the diagnostic community for over 30 years and has been known for the continued development of innovative IHC products.
What is Immunohistochemistry?
Immunohistochemistry is a well-established, highly sensitive method that allows the localization of an antigen within a cell or a tissue with high resolution. IHC technique is based on a primary antibody that specifically binds to its complementary antigen. The bound antigen-antibody complexes are then visualized using chemically linked enzymes, dyes, or fluorescent labels. The method combines molecular detection with morphological features and can be used on formalin-fixed paraffin-embedded (FFPE) sections, frozen sections, and other cytological preparations. IHC is also used for the elucidation of differential diagnoses, a limitation for conventional hematoxylin and eosin analysis. The breakthrough developments of a) monoclonal antibodies, b) antigen exposure technique in preserved tissues, c) sensitive visualization methods, and d) automated strainers have made IHC an indispensable tool for modern molecular diagnostic laboratories.